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LITAF
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10. Belongs to the CDIP1/LITAF family. Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Oncoprotein; Transcription factor |
| Chromosomal Location of mouse Ortholog: 16|16 A1 |
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Cellular Component:
cytoplasm; cytoplasmic side of early endosome membrane; cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; cytoplasmic side of plasma membrane; endosome; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; membrane; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; WW domain binding; zinc ion binding
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Biological Process:
cellular response to lipopolysaccharide; negative regulation of NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; regulation of cytokine production; regulation of macrophage cytokine production; response to lipopolysaccharide
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Reference #:
Q9JLJ0
(UniProtKB)
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Alt. Names/Synonyms: 3222402J11Rik; C85531; Estrogen-enhanced transcript protein; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Litaf; LITAF-like protein; LPS-induced TN factor; LPS-induced TNF-alpha factor homolog; mEET; N4WB; N4wbp3; NEDD4 WW domain-binding protein 3; Tbx1
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Gene Symbols: Litaf
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Molecular weight:
16,946 Da
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Basal Isoelectric point:
5.55
Predict pI for various phosphorylation states
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