SREBP-1 iso3 Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Belongs to the SREBP family. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi membrane; integral component of membrane; nuclear envelope; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme activator activity; nuclear receptor activity; protein binding; protein dimerization activity; protein kinase binding; protein-containing complex binding; RNA polymerase II regulatory region sequence-specific DNA binding; sterol response element binding
Biological Process:  aging; cellular response to fatty acid; cellular response to starvation; cholesterol metabolic process; circadian rhythm; fat cell differentiation; insulin receptor signaling pathway; intracellular receptor signaling pathway; lipid biosynthetic process; lipid metabolic process; lung development; mRNA transcription by RNA polymerase II; negative regulation of insulin secretion; negative regulation of transcription by RNA polymerase II; positive regulation of catalytic activity; positive regulation of cholesterol biosynthetic process; positive regulation of histone deacetylation; positive regulation of transcription by RNA polymerase II; positive regulation of triglyceride biosynthetic process; regulation of autophagy of mitochondrion; regulation of cholesterol biosynthetic process; regulation of fatty acid metabolic process; regulation of heart rate by chemical signal; regulation of protein stability; regulation of protein targeting to mitochondrion; regulation of transcription by RNA polymerase II; response to cAMP; response to food; response to glucagon; response to glucose; response to progesterone; response to retinoic acid
Disease: Ifap Syndrome 2; Mucoepithelial Dysplasia, Hereditary
Reference #:  P36956-3 (UniProtKB)
Alt. Names/Synonyms: BHLHD1; Class D basic helix-loop-helix protein 1; IFAP2; Processed sterol regulatory element-binding protein 1; SRBP1; SREBF1; SREBP-1; SREBP-1 iso3; SREBP-1c; SREBP1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1; Transcription factor SREBF1
Gene Symbols: SREBF1
Molecular weight: 111,102 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Select Structure to View Below

SREBP-1 iso3

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene