SREBP-1
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Belongs to the SREBP family. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor |
Chromosomal Location of human Ortholog: 17p11.2 |
Cellular Component:
chromatin; cytoplasm; cytosol; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi membrane; nuclear envelope; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; protein dimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; sterol response element binding; transcription coregulator binding
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Biological Process:
cellular response to fatty acid; cellular response to starvation; cholesterol biosynthetic process; circadian rhythm; fat cell differentiation; insulin receptor signaling pathway; insulin secretion; intracellular receptor signaling pathway; lipid biosynthetic process; lipid metabolic process; lung development; mRNA transcription by RNA polymerase II; negative regulation of insulin secretion; negative regulation of transcription by RNA polymerase II; negative regulation of triglyceride metabolic process; positive regulation of cholesterol biosynthetic process; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of triglyceride biosynthetic process; regulation of autophagy of mitochondrion; regulation of fatty acid metabolic process; regulation of heart rate by chemical signal; regulation of lipid storage; regulation of protein stability; regulation of protein targeting to mitochondrion; regulation of transcription by RNA polymerase II; response to cAMP; response to ethanol; response to food; response to glucagon; response to glucose; response to progesterone; response to retinoic acid; response to xenobiotic stimulus; SREBP signaling pathway
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Reference #:
P36956
(UniProtKB)
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Alt. Names/Synonyms: BHLHD1; Class D basic helix-loop-helix protein 1; IFAP2; Processed sterol regulatory element-binding protein 1; SRBP1; SREBF1; SREBP-1; SREBP-1c; SREBP1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1; Transcription factor SREBF1
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Gene Symbols: SREBF1
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Molecular weight:
121,675 Da
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Basal Isoelectric point:
8.43
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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