NR1I3 Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Belongs to the nuclear hormone receptor family. NR1 subfamily. Predominantly expressed in liver. 15 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of human Ortholog: 1q23.3
Cellular Component:  chromatin; cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
Biological Process:  cell differentiation; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II; osteoblast differentiation; positive regulation of transcription by RNA polymerase II; signal transduction
Reference #:  Q14994 (UniProtKB)
Alt. Names/Synonyms: CAR; CAR1; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; Constitutive androstane receptor; MB67; MGC150433; MGC97144; MGC97209; NR1I3; Nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67
Gene Symbols: NR1I3
Molecular weight: 39,942 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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