NR1I3 Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 1 H3|1 79.21 cM
Cellular Component:  cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  cell differentiation; multicellular organism development; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  O35627 (UniProtKB)
Alt. Names/Synonyms: AA209988; AI551208; CAR; CAR-beta; Care2; Constitutive androstane receptor; constitutively transactivates RAREs; ESTM32; MB67; MGC107281; Nr1i3; Nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; Orphan nuclear receptor MB67; OTTMUSP00000025500
Gene Symbols: Nr1i3
Molecular weight: 40,913 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
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NR1I3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA