KIBRA Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. Belongs to the WWC family. KIBRA subfamily. Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11|11 A4
Cellular Component:  cell projection; cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; ruffle membrane
Molecular Function:  kinase binding; molecular adaptor activity; protein binding, bridging; transcription coactivator activity
Biological Process:  cell migration; negative regulation of hippo signaling; negative regulation of organ growth; negative regulation of transcription by RNA polymerase II; positive regulation of MAPK cascade; regulation of hippo signaling
Reference #:  Q5SXA9 (UniProtKB)
Alt. Names/Synonyms: AA408228; AU017197; BC037006; Kiaa0869; KIBRA; Kidney and brain protein; MGC47054; mKIAA0869; OTTMUSP00000005593; Protein KIBRA; protein WWC1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1; Wwc1
Gene Symbols: Wwc1
Molecular weight: 124,110 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene