ROR2 a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group
Chromosomal Location of Human Ortholog: 9q22.31
Cellular Component:  axon; cell soma; cell surface; cytoplasm; dendrite; integral component of plasma membrane; microtubule; plasma membrane; receptor complex
Molecular Function:  ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; frizzled binding; MAP kinase kinase kinase activity; metal ion binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding
Biological Process:  astrocyte development; BMP signaling pathway; bone mineralization; cartilage condensation; cell differentiation; cell fate commitment; embryonic digit morphogenesis; embryonic genitalia morphogenesis; inner ear morphogenesis; JNK cascade; macrophage migration; male genitalia development; multicellular organism development; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of signal transduction; peptidyl-tyrosine phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of JUN kinase activity; positive regulation of kinase activity; positive regulation of macrophage differentiation; positive regulation of protein kinase C activity; positive regulation of protein phosphorylation; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription, DNA-templated; signal transduction; smoothened signaling pathway; somitogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Brachydactyly, Type B1; Robinow Syndrome, Autosomal Recessive
Reference #:  Q01974 (UniProtKB)
Alt. Names/Synonyms: BDB; BDB1; MGC163394; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; receptor tyrosine kinase-like orphan receptor 2; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2
Gene Symbols: ROR2
Molecular weight: 104,757 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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