ROR2 Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group
Chromosomal Location of Human Ortholog: 9q22.31
Cellular Component:  cell surface; clathrin-coated endocytic vesicle membrane; dendrite; microtubule; neuronal cell body; plasma membrane
Molecular Function:  ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; frizzled binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; Wnt-protein binding
Biological Process:  astrocyte development; BMP signaling pathway; bone mineralization; cartilage condensation; cell fate commitment; embryonic digit morphogenesis; embryonic genitalia morphogenesis; inner ear morphogenesis; JNK cascade; macrophage migration; male genitalia development; multicellular organism development; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; peptidyl-tyrosine phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of JUN kinase activity; positive regulation of macrophage differentiation; positive regulation of protein kinase C activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription, DNA-templated; signal transduction; SMAD protein signal transduction; smoothened signaling pathway; somitogenesis; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway
Disease: Brachydactyly, Type B1; Robinow Syndrome, Autosomal Recessive
Reference #:  Q01974 (UniProtKB)
Alt. Names/Synonyms: BDB; BDB1; MGC163394; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; receptor tyrosine kinase like orphan receptor 2; receptor tyrosine kinase-like orphan receptor 2; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2
Gene Symbols: ROR2
Molecular weight: 104,757 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ROR2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene