DDX8 Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  catalytic step 2 spliceosome; nuclear body; nucleoplasm; nucleus; spliceosomal complex; U2-type catalytic step 2 spliceosome
Molecular Function:  ATP binding; ATP-dependent 3'-5' RNA helicase activity; helicase activity; hydrolase activity; identical protein binding; nucleic acid binding; nucleotide binding; RNA binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; RNA splicing; spliceosomal complex disassembly
Reference #:  A2A4P0 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase DHX8; Ddx8; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8; DEAH (Asp-Glu-Ala-His) box polypeptide 8; DEAH box protein 8; Dhx8; KIAA4096; mDEAH; mDEAH6; MGC31290; mKIAA4096; MKIAA4096 protein; OTTMUSP00000002846; RNA helicase
Gene Symbols: Dhx8
Molecular weight: 142,572 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
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DDX8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene