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GCFC
Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. Belongs to the GCF family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Spliceosome; Transcription factor |
| Chromosomal Location of mouse Ortholog: 16|16 C3.3 |
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Cellular Component:
nucleus
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Molecular Function:
DNA binding; histone methyltransferase binding; transcription factor binding
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Biological Process:
mRNA splicing, via spliceosome; muscle organ development; positive regulation of myoblast proliferation; positive regulation of transcription by RNA polymerase II; regulation of skeletal muscle satellite cell proliferation; transcription by RNA polymerase II
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Reference #:
P58501
(UniProtKB)
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Alt. Names/Synonyms: 1810007M14Rik; C21orf66; GC-rich sequence DNA-binding factor 1; GC-rich sequence DNA-binding factor homolog; Gcfc; Gcfc1; OTTMUSP00000017451; PAX3 and PAX7 binding protein 1; PAX3- and PAX7-binding protein 1; Pax3/; PAX3/7BP; PAXB1; Paxbp1
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Gene Symbols: Paxbp1
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Molecular weight:
104,836 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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