PC4 a transcriptional coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, nonspecifically to double-stranded DNA (ds DNA). Interacts with CSTF2. Its activity is controlled by phosphorylation of the regulatory domain. Phosphorylation inactivates both dsDNA-binding and cofactor function. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15|15 A1
Cellular Component:  nucleolus; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding; sequence-specific double-stranded DNA binding; single-stranded DNA binding; transcription coactivator activity
Biological Process:  positive regulation of transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; SMAD protein signal transduction
Reference #:  P11031 (UniProtKB)
Alt. Names/Synonyms: Activated RNA polymerase II transcriptional coactivator p15; AI842364; OTTMUSP00000027771; OTTMUSP00000027772; p14; P15; P9; PC4; Positive cofactor 4; RNA polymerase II transcriptional coactivator; Rpo2tc1; Single-stranded DNA-binding protein p9; Sub1; SUB1 homolog; SUB1 homolog (S. cerevisiae); TCP4
Gene Symbols: Sub1
Molecular weight: 14,427 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
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PC4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA