PC4 General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). Belongs to the transcriptional coactivator PC4 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15|15 A1
Cellular Component:  nucleolus; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding; sequence-specific double-stranded DNA binding; single-stranded DNA binding; transcription coactivator activity
Biological Process:  positive regulation of transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; SMAD protein signal transduction
Reference #:  P11031 (UniProtKB)
Alt. Names/Synonyms: Activated RNA polymerase II transcriptional coactivator p15; AI842364; OTTMUSP00000027771; OTTMUSP00000027772; p14; P15; P9; PC4; Positive cofactor 4; RNA polymerase II transcriptional coactivator; Rpo2; Rpo2tc1; Single-stranded DNA-binding protein p9; Sub1; SUB1 homolog; SUB1 homolog (S. cerevisiae); SUB1 homolog, transcriptional regulator; TCP4
Gene Symbols: Sub1
Molecular weight: 14,427 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
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PC4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA