DUSP4 Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Protein phosphatase, dual-specificity
Chromosomal Location of mouse Ortholog: 8|8 A4
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  hydrolase activity; MAP kinase serine/threonine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process:  dephosphorylation; inactivation of MAPK activity; negative regulation of ERK1 and ERK2 cascade; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  Q8BFV3 (UniProtKB)
Alt. Names/Synonyms: 2700078F24Rik; AI844617; BB104621; dual specificity phosphatase 4; Dual specificity protein phosphatase 4; DUS4; Dusp4; E130306H24Rik; MKP; MKP2; OTTMUSP00000018459
Gene Symbols: Dusp4
Molecular weight: 43,372 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene