|
MX2
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: G protein regulator, misc. |
| Chromosomal Location of Human Ortholog: 16 C4|16 57.51 cM |
|
Cellular Component:
cytoplasm; membrane; mitochondrial membrane; nucleus
|
|
Molecular Function:
GTPase activity; microtubule binding
|
|
Biological Process:
defense response to virus; dynamin family protein polymerization involved in mitochondrial fission; innate immune response; membrane fusion; mitochondrial fission
|
|
Reference #:
Q9WVP9
(UniProtKB)
|
|
Alt. Names/Synonyms: AI528743; Interferon-induced GTP-binding protein Mx2; MX dynamin-like GTPase 2; Mx-2; Mx2; myxovirus (influenza virus) resistance 2; Myxovirus resistance protein 2
|
|
Gene Symbols: Mx2
|
|
Molecular weight:
74,292 Da
|
|
Basal Isoelectric point:
5.32
Predict pI for various phosphorylation states
|
