MX2 Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 16 C4|16 57.51 cM
Cellular Component:  cytoplasm; membrane; mitochondrial membrane; nucleus
Molecular Function:  GTPase activity; microtubule binding
Biological Process:  defense response to virus; dynamin family protein polymerization involved in mitochondrial fission; innate immune response; membrane fusion; mitochondrial fission
Reference #:  Q9WVP9 (UniProtKB)
Alt. Names/Synonyms: AI528743; Interferon-induced GTP-binding protein Mx2; MX dynamin-like GTPase 2; Mx-2; Mx2; myxovirus (influenza virus) resistance 2; Myxovirus resistance protein 2
Gene Symbols: Mx2
Molecular weight: 74,292 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein