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MX2
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein regulator, misc. |
| Chromosomal Location of mouse Ortholog: 16 C4|16 57.51 cM |
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Cellular Component:
cytoplasm; cytosol; membrane; microtubule; nuclear membrane; nuclear pore; nucleus; perinuclear region of cytoplasm
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Molecular Function:
GTP binding; GTPase activity; identical protein binding; microtubule binding
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Biological Process:
defense response to virus; innate immune response; negative regulation of viral genome replication; response to bacterium; response to type I interferon; response to virus
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Reference #:
Q9WVP9
(UniProtKB)
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Alt. Names/Synonyms: AI528743; Interferon-induced GTP-binding protein Mx2; MX dynamin-like GTPase 2; Mx-2; Mx2; myxovirus (influenza virus) resistance 2; Myxovirus resistance protein 2
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Gene Symbols: Mx2
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Molecular weight:
74,292 Da
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Basal Isoelectric point:
5.32
Predict pI for various phosphorylation states
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