islet-2 Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9|9 B
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; sequence-specific DNA binding
Biological Process:  axonogenesis; multicellular organism development; negative regulation of neuron differentiation; neuron fate commitment; neuron fate specification; regulation of transcription, DNA-templated; retinal ganglion cell axon guidance; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation
Reference #:  Q9CXV0 (UniProtKB)
Alt. Names/Synonyms: 3110001N10Rik; Insulin gene enhancer protein ISL-2; insulin related protein 2 (islet 2); Isl2; isle; islet 2; Islet-2; MGC171130
Gene Symbols: Isl2
Molecular weight: 39,728 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene