GUCY2C an intestinal receptor for the E.coli enterotoxin, and the paracrine hormones guanylin and uroguanylin. Regulates intestinal cell proliferation. Converts guanosine-5'-triphosphate to cyclic guanosine monophosphate (cGMP). Elevated intracellular cGMP modulates intestinal fluid-ion homeostasis and differentiation of crypt enterocytes. cGMP inhibits colonic cell proliferation by inducing p21 and cell cycle arrest. mice lacking GC-C display increased cell proliferation in colonic crypts. It functions as a tumor suppressor; its loss disrupts intestinal homeostasis and promotes tumorigenesis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Note: This description may include information from UniProtKB.
Protein type: EC; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.
Chromosomal Location of Human Ortholog: 6 G1|6 66.67 cM
Cellular Component:  endoplasmic reticulum; integral component of membrane; membrane; plasma membrane
Molecular Function:  ATP binding; GTP binding; guanylate cyclase activity; lyase activity; nucleotide binding; peptide receptor activity; phosphorus-oxygen lyase activity; protein kinase activity; toxic substance binding
Biological Process:  cGMP biosynthetic process; cyclic nucleotide biosynthetic process; intracellular signal transduction; protein phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of cell proliferation; response to toxic substance; signal transduction
Reference #:  Q3UWA6 (UniProtKB)
Alt. Names/Synonyms: AI893437; GC-C; Gcc; guanylate cyclase 2c; Guanylyl cyclase C; Guc2c; Gucy2c; heat stable enterotoxin receptor; Heat-stable enterotoxin receptor; Intestinal guanylate cyclase; MGC107510; STA receptor
Gene Symbols: Gucy2c
Molecular weight: 123,232 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene