FGD6 May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 10|10 C2
Cellular Component:  cytoplasm; cytoskeleton
Molecular Function:  guanyl-nucleotide exchange factor activity; metal ion binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  regulation of GTPase activity; regulation of Rho protein signal transduction
Reference #:  Q69ZL1 (UniProtKB)
Alt. Names/Synonyms: AA123052; ethanol decreased 4; Etohd4; Fgd6; FYVE, RhoGEF and PH domain containing 6; FYVE, RhoGEF and PH domain-containing protein 6; Kiaa1362; ZFYVE24
Gene Symbols: Fgd6
Molecular weight: 155,169 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene