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FGD6
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rac/Rho |
| Chromosomal Location of mouse Ortholog: 10|10 C2 |
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Cellular Component:
cytoplasm; cytoskeleton
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Molecular Function:
guanyl-nucleotide exchange factor activity; metal ion binding
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Biological Process:
regulation of GTPase activity
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Reference #:
Q69ZL1
(UniProtKB)
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Alt. Names/Synonyms: AA123052; ethanol decreased 4; Etohd; Etohd4; Fgd6; FYVE, RhoGEF and PH domain containing 6; FYVE, RhoGEF and PH domain-containing protein 6; Kiaa1362; ZFYVE2; ZFYVE24
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Gene Symbols: Fgd6
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Molecular weight:
155,169 Da
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Basal Isoelectric point:
8.09
Predict pI for various phosphorylation states
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