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ALK7
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; STKR1 subfamily; TKL group |
| Chromosomal Location of mouse Ortholog: 2|2 C1.1 |
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Cellular Component:
activin receptor complex; cell surface; membrane; plasma membrane
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Molecular Function:
activin binding; activin receptor activity, type I; ATP binding; BMP receptor binding; growth factor binding; kinase activity; metal ion binding; nodal binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transferase activity; transmembrane receptor protein serine/threonine kinase activity
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Biological Process:
activin receptor signaling pathway; apoptotic nuclear changes; apoptotic process; cell differentiation; cellular response to growth factor stimulus; determination of left/right symmetry; in utero embryonic development; insulin secretion; lipid storage; negative regulation of chorionic trophoblast cell proliferation; negative regulation of insulin secretion; negative regulation of trophoblast cell migration; nervous system development; nodal signaling pathway; phosphorylation; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein phosphorylation; regulation of apoptotic process; response to dietary excess; response to glucose; response to insulin; transforming growth factor beta receptor complex assembly; transmembrane receptor protein serine/threonine kinase signaling pathway; trophectodermal cell proliferation
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Reference #:
Q8K348
(UniProtKB)
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Alt. Names/Synonyms: activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACV1C; Acvr1c; ACVRLK7; Alk; ALK-7; Alk7; C230097P10
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Gene Symbols: Acvr1c
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Molecular weight:
54,700 Da
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Basal Isoelectric point:
7.73
Predict pI for various phosphorylation states
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