CENTD1 Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF
Chromosomal Location of Human Ortholog: 5|5 C3.1
Cellular Component:  cytoplasm
Molecular Function:  GTPase activator activity; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding
Biological Process:  positive regulation of GTPase activity; signal transduction
Reference #:  Q8BZ05 (UniProtKB)
Alt. Names/Synonyms: Arap2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; centaurin, delta 1; Centaurin-delta-1; Centd1; Cnt-d1; Gm148; Kiaa0580; mKIAA0580; PARX protein
Gene Symbols: Arap2
Molecular weight: 193,398 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
Select Structure to View Below

CENTD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene