VCIP135 Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of mouse Ortholog: 1|1 A2
Cellular Component:  cytoplasm; endoplasmic reticulum; Golgi apparatus; synapse
Molecular Function:  cysteine-type peptidase activity; hydrolase activity; peptidase activity; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity
Biological Process:  endoplasmic reticulum membrane fusion; Golgi organization; Golgi reassembly; mitotic cell cycle; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; proteolysis
Reference #:  Q8CDG3 (UniProtKB)
Alt. Names/Synonyms: 4932442A08; 5730421J18Rik; 5730538E15Rik; Deubiquitinating protein VCIP135; mKIAA1850; OTTMUSP00000024897; valosin containing protein (p97)/p47 complex interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; Vcip; VCIP1; Vcip135; Vcpip1
Gene Symbols: Vcpip1
Molecular weight: 134,503 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene