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VCIP135
Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of mouse Ortholog: 1|1 A2 |
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Cellular Component:
cytoplasm; endoplasmic reticulum; Golgi apparatus; nucleus; synapse
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Molecular Function:
cysteine-type deubiquitinase activity; cysteine-type peptidase activity; hydrolase activity; peptidase activity
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Biological Process:
DNA damage response; DNA repair; endoplasmic reticulum membrane fusion; Golgi organization; Golgi reassembly; protein deubiquitination; protein K11-linked deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; protein-DNA covalent cross-linking repair; proteolysis; regulation of protein localization to chromatin
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Reference #:
Q8CDG3
(UniProtKB)
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Alt. Names/Synonyms: 4932442A08; 5730421J18Rik; 5730538E15Rik; Deubiquitinating protein VCIP135; Deubiquitinating protein VCPIP1; mKIAA1850; OTTMUSP00000024897; valosin containing protein (p97)/p47 complex interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; Vcip; VCIP1; Vcip135; Vcpip1
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Gene Symbols: Vcpip1
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Molecular weight:
134,503 Da
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Basal Isoelectric point:
6.72
Predict pI for various phosphorylation states
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