SCEL May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14|14 E2.3
Cellular Component:  cytoplasm; membrane; perinuclear region of cytoplasm
Molecular Function:  metal ion binding
Biological Process:  embryo development ending in birth or egg hatching; epidermis development; keratinocyte differentiation; positive regulation of canonical Wnt signaling pathway
Reference #:  Q9EQG3 (UniProtKB)
Alt. Names/Synonyms: 9230114I02Rik; MGC132819; MGC132820; Scel; Sciellin
Gene Symbols: Scel
Molecular weight: 72,972 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene