FADD
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Apoptosis |
Chromosomal Location of human Ortholog: 11q13.3 |
Cellular Component:
CD95 death-inducing signaling complex; cell body; cytoplasm; cytoplasmic side of plasma membrane; cytosol; death-inducing signaling complex; plasma membrane; ripoptosome
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Molecular Function:
caspase binding; death effector domain binding; death receptor binding; identical protein binding; molecular adaptor activity; protease binding; protein binding; protein-containing complex binding; receptor serine/threonine kinase binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
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Biological Process:
activation of cysteine-type endopeptidase activity; apoptotic process; apoptotic signaling pathway; behavioral response to cocaine; cellular response to mechanical stimulus; death-inducing signaling complex assembly; defense response to virus; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; innate immune response; kidney development; lymph node development; motor neuron apoptotic process; necroptotic signaling pathway; negative regulation of activation-induced cell death of T cells; negative regulation of necroptotic process; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptotic process; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of innate immune response; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type I interferon-mediated signaling pathway; positive regulation of type II interferon production; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development; TRAIL-activated apoptotic signaling pathway
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Disease: Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations
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Reference #:
Q13158
(UniProtKB)
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Alt. Names/Synonyms: FADD; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Protein FADD
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Gene Symbols: FADD
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Molecular weight:
23,279 Da
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Basal Isoelectric point:
5.48
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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Toll-Like Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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