APC1 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 2|2 F1
Cellular Component:  anaphase-promoting complex; nucleus
Molecular Function:  protein binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; metaphase/anaphase transition of mitotic cell cycle; protein K11-linked ubiquitination
Reference #:  P53995 (UniProtKB)
Alt. Names/Synonyms: 2610021O03Rik; AI047775; AI853536; Anapc1; anaphase promoting complex subunit 1; Anaphase-promoting complex subunit 1; APC1; AW547281; Cyclosome subunit 1; Mcpr; meiotic check point regulator; Mitotic checkpoint regulator; OTTMUSP00000016356; Testis-specific gene 24 protein; Tsg24
Gene Symbols: Anapc1
Molecular weight: 215,994 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
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APC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene