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GUCY2D
a transmembrane guanylyl cyclase enzyme with a tyrosine kinse domain. Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells. The pseudokinase domains of guanylyl cyclases have been reported to allosterically increase the affinity of their catalytic domains for substrate. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 11 B3|11 42.51 cM |
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Cellular Component:
cell projection; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane
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Molecular Function:
adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; identical protein binding; lyase activity; nucleotide binding; peptide receptor activity; phosphorus-oxygen lyase activity; protein homodimerization activity; protein kinase activity; protein-containing complex binding
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Biological Process:
cGMP biosynthetic process; cGMP-mediated signaling; cyclic nucleotide biosynthetic process; intracellular signal transduction; protein phosphorylation; receptor guanylyl cyclase signaling pathway; response to stimulus; visual perception
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Reference #:
P52785
(UniProtKB)
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Alt. Names/Synonyms: GC-E; GC1; Guanylate cyclase 2E; guanylyl cyclase 2e; Guanylyl cyclase GC-E; Guc2e; GUCY2D; Gucy2e; OTTMUSP00000006166; OTTMUSP00000006167; Retinal guanylyl cyclase 1; ROS-; ROS-GC1
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Gene Symbols: Gucy2e
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Molecular weight:
120,638 Da
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Basal Isoelectric point:
7.85
Predict pI for various phosphorylation states
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