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RREB1
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 13|13 A3.3 |
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Cellular Component:
fibrillar center; nuclear speck; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of brown fat cell differentiation; positive regulation of epithelial cell migration; positive regulation of lamellipodium morphogenesis; positive regulation of mammary gland epithelial cell proliferation; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of transcription by RNA polymerase II; positive regulation of wound healing, spreading of epidermal cells; regulation of transcription by RNA polymerase II
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Reference #:
Q3UH06
(UniProtKB)
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Alt. Names/Synonyms: 1110037N09Rik; AA414966; B930013M22Rik; ras responsive element binding protein 1; Ras-responsive element-binding protein 1; RAS-responsive zinc finger transcription factor RREB; RREB-1; Rreb1
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Gene Symbols: Rreb1
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Molecular weight:
184,154 Da
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Basal Isoelectric point:
6.28
Predict pI for various phosphorylation states
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