SRPK3 Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Exclusively expressed in skeletal and heart muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); SRPK family
Chromosomal Location of Human Ortholog: X|X A7.3
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell differentiation; intracellular signal transduction; multicellular organism development; muscle organ development; muscle tissue development; phosphorylation; protein phosphorylation; regulation of gene expression; regulation of mRNA processing; skeletal muscle tissue development; spliceosomal complex assembly
Reference #:  Q9Z0G2 (UniProtKB)
Alt. Names/Synonyms: MSSK-1; Mssk1; Muscle-specific serine kinase 1; OTTMUSP00000019243; serine/arginine-rich protein specific kinase 3; Serine/arginine-rich protein-specific kinase 3; serine/threonine kinase 23, muscle-specific serine kinase 1 70; Serine/threonine-protein kinase 23; Serine/threonine-protein kinase SRPK3; SR-protein-specific kinase 3; Srpk3; SRSF protein kinase 3; Stk23
Gene Symbols: Srpk3
Molecular weight: 62,365 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene