LIME1 Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2|2 H4
Cellular Component:  B cell receptor complex; integral component of membrane; membrane; plasma membrane
Molecular Function:  protein binding; protein kinase binding
Biological Process:  adaptive immune response; B cell receptor signaling pathway; immune system process; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of MAP kinase activity; regulation of NIK/NF-kappaB signaling; regulation of phosphatidylinositol 3-kinase signaling; regulation of release of sequestered calcium ion into cytosol; regulation of transcription by RNA polymerase II; T cell receptor signaling pathway
Reference #:  Q9EQR5 (UniProtKB)
Alt. Names/Synonyms: 2810038K19Rik; Lck interacting transmembrane adaptor 1; Lck-interacting molecule; Lck-interacting transmembrane adapter 1; Lime; Lime1; OTTMUSP00000018005
Gene Symbols: Lime1
Molecular weight: 29,551 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene