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PDHK1
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Belongs to the PDK/BCKDK protein kinase family. Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: ATYPICAL group; EC 2.7.11.2; Kinase, protein; Mitochondrial; PDHK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical |
| Chromosomal Location of mouse Ortholog: 2|2 C3 |
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Cellular Component:
mitochondrial pyruvate dehydrogenase complex; mitochondrion; plasma membrane; pyruvate dehydrogenase complex
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Molecular Function:
ATP binding; identical protein binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity
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Biological Process:
carbohydrate metabolic process; cell population proliferation; cell surface receptor signaling pathway; glucose metabolic process; hypoxia-inducible factor-1alpha signaling pathway; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to oxidative stress; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; regulation of glucose metabolic process
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Reference #:
Q8BFP9
(UniProtKB)
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Alt. Names/Synonyms: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; B830012B01; D530020C15Rik; OTTMUSP00000014262; PDH kinase 1; PDHK1; Pdk1; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; Pyruvate dehydrogenase kinase isoform 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
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Gene Symbols: Pdk1
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Molecular weight:
48,995 Da
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Basal Isoelectric point:
8.36
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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