TAO3 Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of MAPKK activity; activation of protein kinase activity; cellular response to DNA damage stimulus; DNA repair; MAPK cascade; mitotic G2 DNA damage checkpoint; negative regulation of JNK cascade; phosphorylation; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q8BYC6 (UniProtKB)
Alt. Names/Synonyms: 2900006A08Rik; A130052D22; A430105I05Rik; OTTMUSP00000031319; OTTMUSP00000031329; Serine/threonine-protein kinase TAO3; TAO kinase 3; TAO3; Taok3; Thousand and one amino acid protein 3
Gene Symbols: Taok3
Molecular weight: 105,336 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
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TAO3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene