MEKK4 Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of Human Ortholog: 17 8.42 cM|17 A1
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of MAPKK activity; activation of protein kinase activity; chorionic trophoblast cell differentiation; determination of dorsal identity; intracellular signal transduction; male germ-line sex determination; phosphorylation; placenta development; positive regulation of JUN kinase activity; positive regulation of p38MAPK cascade; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of gene expression; response to UV-C; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  O08648 (UniProtKB)
Alt. Names/Synonyms: D17Rp; D17Rp1; D17Rp17; D17Rp17e; M3K4; Map3k4; MAPK/ERK kinase kinase 4; MAPKK; MAPKKK4; MEK kinase 4; Mek4b; MEKK 4; Mekk4; mitogen activated protein kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase 4; mKIAA0213; MTK1; RP17; Rp17a; T-associated sex reversal; Tas
Gene Symbols: Map3k4
Molecular weight: 179,834 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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MEKK4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene