EMSY Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Transcription regulation
Chromosomal Location of Human Ortholog: 7|7 E1
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  protein binding; protein homodimerization activity
Biological Process:  cellular response to DNA damage stimulus; chromatin organization; DNA repair; regulation of transcription, DNA-templated
Reference #:  Q8BMB0 (UniProtKB)
Alt. Names/Synonyms: 2210018M11Rik; 2310016L09Rik; AU019521; AU019557; BRCA2-interacting transcriptional repressor EMSY; Emsy; MGC101920; Protein EMSY; RIKEN cDNA 2210018M11 gene
Gene Symbols: Emsy
Molecular weight: 135,291 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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EMSY

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene