CCNA2 Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 3 B|3 17.67 cM
Cellular Component:  cyclin A2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; female pronucleus; male pronucleus; nucleoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein domain specific binding; protein kinase binding
Biological Process:  cell cycle; cell cycle G1/S phase transition; cell division; DNA-templated transcription; G2/M transition of mitotic cell cycle; mitotic cell cycle phase transition; positive regulation of DNA-templated transcription; positive regulation of fibroblast proliferation; post-translational protein modification; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA replication
Reference #:  P51943 (UniProtKB)
Alt. Names/Synonyms: AA408589; Ccn; Ccn-; Ccn-1; Ccn1; Ccna; Ccna2; Cyc; Cyca; Cyca2; cyclin A2; Cyclin A2 (Cyclin A); Cyclin-A; Cyclin-A2; OTTMUSP00000006886
Gene Symbols: Ccna2
Molecular weight: 47,269 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA