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CCNA2
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Nuclear receptor co-regulator |
| Chromosomal Location of mouse Ortholog: 3 B|3 17.67 cM |
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Cellular Component:
cyclin A2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; female pronucleus; male pronucleus; nucleoplasm; nucleus
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Molecular Function:
cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein domain specific binding; protein kinase binding
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Biological Process:
cell cycle; cell cycle G1/S phase transition; cell division; G2/M transition of mitotic cell cycle; histone phosphorylation; mitotic cell cycle phase transition; positive regulation of fibroblast proliferation; positive regulation of transcription, DNA-templated; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA replication
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Reference #:
P51943
(UniProtKB)
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Alt. Names/Synonyms: AA408589; Ccn; Ccn-; Ccn-1; Ccn1; Ccna; Ccna2; Cyc; Cyca; Cyca2; cyclin A2; Cyclin A2 (Cyclin A); Cyclin-A; Cyclin-A2; OTTMUSP00000006886
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Gene Symbols: Ccna2
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Molecular weight:
47,269 Da
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Basal Isoelectric point:
5.81
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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