Lmr3 Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. Belongs to the protein kinase superfamily. Tyr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Lmr family; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 7|7 B3
Cellular Component:  cell projection; Golgi apparatus; integral component of membrane; membrane
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  negative regulation of phosphatase activity; phosphorylation; protein phosphorylation
Reference #:  Q5XJV6 (UniProtKB)
Alt. Names/Synonyms: aatyk3; apoptosis-associated tyrosine kinase 3; BC059845; Lemur tyrosine kinase 3; Lmtk3; MGC90743; Serine/threonine-protein kinase LMTK3
Gene Symbols: Lmtk3
Molecular weight: 150,891 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

Lmr3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene