IGF2BP1 a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 11 D|11 59.08 cM
Cellular Component:  cell projection; CRD-mediated mRNA stability complex; cytoplasm; cytoplasmic stress granule; cytosol; dendrite; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; nucleic acid binding; RNA binding; translation regulator activity
Biological Process:  CRD-mediated mRNA stabilization; mRNA transport; negative regulation of translation; neuronal stem cell population maintenance; pallium cell proliferation in forebrain; regulation of mRNA stability involved in response to stress; regulation of translation; RNA localization
Reference #:  O88477 (UniProtKB)
Alt. Names/Synonyms: AL024068; AW549074; coding region determinant binding protein; Coding region determinant-binding protein; CRD-BP; Crdbp; D030026A21Rik; D11Moh40e; D11Moh45; IF2B1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; Igf2bp1; IMP-1; insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1; insulin-like growth factor 2, binding protein 1; Neilsen; OTTMUSP00000001867; VICKZ family member 1; Vickz1; Zbp1; zipcode binding protein 1; zipcode-binding protein 1
Gene Symbols: Igf2bp1
Molecular weight: 63,451 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IGF2BP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene