TRB2 Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Highly expressed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family
Chromosomal Location of mouse Ortholog: 12|12 A1.1
Cellular Component:  cytoplasm; cytoskeleton; nucleus
Molecular Function:  ATP binding; mitogen-activated protein kinase kinase binding; protein kinase activity; protein kinase inhibitor activity; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein transferase regulator activity
Biological Process:  negative regulation of DNA-binding transcription factor activity; negative regulation of fat cell differentiation; negative regulation of interleukin-10 production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; protein phosphorylation; regulation of MAP kinase activity
Reference #:  Q8K4K3 (UniProtKB)
Alt. Names/Synonyms: AW319517; TRB; TRB-2; TRB2; Trib2; Tribbles homolog 2; tribbles homolog 2 (Drosophila); tribbles pseudokinase 2
Gene Symbols: Trib2
Molecular weight: 38,773 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein