IPO3
Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. Expressed in skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Karyopherin; Nuclear export; Nuclear import; Receptor, misc. |
Chromosomal Location of mouse Ortholog: 6 A3.3|6 12.36 cM |
Cellular Component:
annulate lamellae; cytoplasm; intracellular membrane-bounded organelle; nuclear envelope; nucleus
|
Molecular Function:
identical protein binding; small GTPase binding
|
Biological Process:
protein import into nucleus; protein transport
|
Reference #:
Q6P2B1
(UniProtKB)
|
Alt. Names/Synonyms: 5730544L10Rik; C430013M08Rik; C81142; D6Ertd313; D6Ertd313e; IPO3; KIAA4133; MGC90049; mKIAA4133; Tnpo3; transportin 3; Transportin-3; transportin-SR; Trn-SR
|
Gene Symbols: Tnpo3
|
Molecular weight:
104,170 Da
|
Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
|