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MAGE-G1
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 7|7 C |
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Cellular Component:
chromosome; chromosome, telomeric region; cytoplasm; nucleus; Smc5-Smc6 complex
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Molecular Function:
protein binding; protein dimerization activity
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Biological Process:
cellular response to hydroxyurea; cellular response to radiation; cellular response to UV; DNA damage response; DNA recombination; DNA repair; negative regulation of transcription by RNA polymerase II; positive regulation of protein ubiquitination; regulation of DNA-templated transcription
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Reference #:
Q9CPR8
(UniProtKB)
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Alt. Names/Synonyms: 5730494G16Rik; AI642138; BB044375; HCA; HCA4; mage-g1; MAGE-G1 antigen; Mageg; Mageg1; MAGG1; melanoma antigen, family G, 1; Melanoma-associated antigen G1; Ndnl2; necdin-like 2; Necdin-like protein 2; Non-SMC element 3 homolog; Non-structural maintenance of chromosomes element 3 homolog; NSE3; NSE3 homolog, SMC5-SMC6 complex component; Nsmce3
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Gene Symbols: Nsmce3
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Molecular weight:
31,460 Da
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Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
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