SCN2A Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 2 C1.3|2 38.61 cM
Cellular Component:  axon; axon initial segment; glutamatergic synapse; intercalated disc; membrane; node of Ranvier; paranode region of axon; plasma membrane; presynaptic membrane; sodium channel complex; T-tubule; voltage-gated sodium channel complex
Molecular Function:  calmodulin binding; growth factor binding; leucine zipper domain binding; monoatomic cation channel activity; monoatomic ion channel activity; sodium channel activity; sodium ion binding; voltage-gated monoatomic ion channel activity; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated sodium channel activity
Biological Process:  cellular response to hypoxia; dentate gyrus development; determination of adult lifespan; intrinsic apoptotic signaling pathway in response to osmotic stress; membrane depolarization during action potential; memory; monoatomic ion transport; nerve development; nervous system development; neuron apoptotic process; neuronal action potential; regulation of monoatomic ion transmembrane transport; sodium ion transmembrane transport; sodium ion transport; transmembrane transport
Reference #:  B1AWN6 (UniProtKB)
Alt. Names/Synonyms: 6430408L10; A230052E19Rik; Nav; Nav1.2; OTTMUSP00000013961; Scn; Scn2a; Scn2a1; Scn3a; Sodium channel 21; Sodium channel protein; Sodium channel protein type 2 subunit alpha; sodium channel, voltage-gated, type II, alpha; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha polypeptide 1; voltage-gated sodium channel Nav1.2 variant a; voltage-gated sodium channel Nav1.2 variant b; Voltage-gated sodium channel subunit alpha Nav1.2
Gene Symbols: Scn2a
Molecular weight: 227,945 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SCN2A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein