|
PGC-1 alpha
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. 9 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 5|5 C1 |
|
Cellular Component:
apical dendrite; chromatin; cytosol; cytosolic ribosome; euchromatin; neuronal cell body; nucleoplasm; nucleus
|
|
Molecular Function:
alpha-tubulin binding; chromatin binding; chromatin DNA binding; DNA binding; lncRNA binding; nuclear estrogen receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; nucleic acid binding; peroxisome proliferator activated receptor binding; promoter-specific chromatin binding; protein binding; RNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transcription factor binding; ubiquitin protein ligase binding
|
|
Biological Process:
adipose tissue development; cellular response to follicle-stimulating hormone stimulus; cellular response to oxidative stress; cellular response to thyroid hormone stimulus; cellular response to transforming growth factor beta stimulus; circadian regulation of gene expression; energy homeostasis; gluconeogenesis; mitochondrion organization; negative regulation of glycolytic process; negative regulation of mitochondrial fission; negative regulation of neuron apoptotic process; negative regulation of protein phosphorylation; negative regulation of signaling receptor activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; neuron apoptotic process; positive regulation of ATP biosynthetic process; positive regulation of cellular respiration; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of fatty acid oxidation; positive regulation of gene expression; positive regulation of mitochondrial DNA metabolic process; positive regulation of mitochondrion organization; positive regulation of muscle tissue development; positive regulation of oxidative phosphorylation uncoupler activity; positive regulation of podocyte apoptotic process; positive regulation of progesterone biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of vascular associated smooth muscle cell proliferation; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of NMDA receptor activity; respiratory electron transport chain; response to activity; response to dietary excess; response to muscle activity; rhythmic process
|
|
Reference #:
O70343
(UniProtKB)
|
|
Alt. Names/Synonyms: A830037N07Rik; Gm11133; OTTMUSP00000026095; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Pgc; PGC-1; PGC-1 alpha; PGC-1-alpha; Pgc-1alpha; Pgc-1alphaa; PGC-1v; Pgc1; Pgc1a; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1; Ppargc1a; PRGC1
|
|
Gene Symbols: Ppargc1a
|
|
Molecular weight:
90,588 Da
|
|
Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
|
|
CST Pathways:
AMPK Signaling
|
mTOR Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
