SEMA5A a single-pass type I membrane protein that may act as positive axonal guidance cues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15 B3.1|15 13.02 cM
Cellular Component:  integral component of membrane; membrane
Molecular Function:  axon guidance receptor activity; chemorepellent activity; chondroitin sulfate proteoglycan binding; heparan sulfate proteoglycan binding; semaphorin receptor binding; syndecan binding
Biological Process:  axon extension; axon guidance; axonal fasciculation; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; cell chemotaxis; cell differentiation; detection of light stimulus involved in visual perception; diencephalon development; multicellular organism development; negative regulation of axon extension involved in axon guidance; negative regulation of cell adhesion; negative regulation of endothelial cell apoptotic process; nervous system development; neural crest cell migration; neuron projection extension; neuron projection guidance; positive chemotaxis; positive regulation of actin filament depolymerization; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell proliferation; positive regulation of extracellular matrix disassembly; positive regulation of protein kinase B signaling; semaphorin-plexin signaling pathway; signal clustering
Reference #:  Q62217 (UniProtKB)
Alt. Names/Synonyms: 5930434A13; 9130201M22Rik; AI464145; M-Sema D; SEM5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; Sema F; Sema5a; Semaf; semaphorin F; Semaphorin-5A; Semaphorin-F; SemF
Gene Symbols: Sema5a
Molecular weight: 120,826 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Select Structure to View Below

SEMA5A

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene