HNK1ST Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. Belongs to the sulfotransferase 2 family. In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe. Note: This description may include information from UniProtKB.
Protein type: EC 2.8.2.-; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 1|1 B
Cellular Component:  Golgi apparatus; integral component of membrane; membrane
Molecular Function:  HNK-1 sulfotransferase activity; sulfotransferase activity; transferase activity
Biological Process:  carbohydrate biosynthetic process; carbohydrate metabolic process; learning; long-term memory; proteoglycan biosynthetic process
Reference #:  Q6PGK7 (UniProtKB)
Alt. Names/Synonyms: AI507003; AU041319; Carbohydrate sulfotransferase 10; Chst10; CHSTA; Hnk-1; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; ST
Gene Symbols: Chst10
Molecular weight: 42,055 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene