XPG Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Deoxyribonuclease; EC 3.1.-.-
Chromosomal Location of Human Ortholog: 1 C1.1|1 23.55 cM
Cellular Component:  nucleotide-excision repair complex; nucleus
Molecular Function:  bubble DNA binding; catalytic activity; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; endonuclease activity; hydrolase activity; hydrolase activity, acting on ester bonds; metal ion binding; nuclease activity; protein homodimerization activity; protein N-terminus binding; protein-containing complex binding; RNA polymerase II complex binding; single-stranded DNA binding
Biological Process:  cellular response to DNA damage stimulus; determination of adult lifespan; DNA repair; multicellular organism growth; negative regulation of apoptotic process; nucleotide-excision repair; nucleotide-excision repair, DNA incision, 3'-to lesion; response to UV; response to UV-C; transcription-coupled nucleotide-excision repair; UV protection
Reference #:  P35689 (UniProtKB)
Alt. Names/Synonyms: DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells homolog; Ercc-5; Ercc5; excision repair cross-complementing rodent repair deficiency, complementation group 5; MGC176031; OTTMUSP00000023812; Xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; Xpg
Gene Symbols: Ercc5
Molecular weight: 130,715 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene