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UNC5D
Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell. Belongs to the unc-5 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 8|8 A2 |
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Cellular Component:
cell surface; membrane; plasma membrane
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Molecular Function:
netrin receptor activity; protein binding
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Biological Process:
apoptotic process; axon guidance; cell-cell adhesion via plasma-membrane adhesion molecules; multicellular organism development; netrin-activated signaling pathway; pyramidal neuron differentiation; regulation of neuron migration; signal transduction
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Reference #:
Q8K1S2
(UniProtKB)
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Alt. Names/Synonyms: D930029E11Rik; KIAA1777; mKIAA1777; Netrin receptor UNC5D; Protein unc-5 homolog 4; Protein unc-5 homolog D; unc-5 homolog 4; unc-5 homolog D (C. elegans); unc-5 netrin receptor D; unc5 homolog 4; Unc5d; Unc5h; Unc5h4
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Gene Symbols: Unc5d
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Molecular weight:
106,352 Da
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Basal Isoelectric point:
5.76
Predict pI for various phosphorylation states
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