GluR3 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: X A4|X 23.19 cM
Cellular Component:  AMPA glutamate receptor complex; asymmetric synapse; cell junction; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; integral component of membrane; integral component of postsynaptic density membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; neuronal cell body; parallel fiber to Purkinje cell synapse; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; protein-containing complex; synapse; synaptic cleft; terminal bouton
Molecular Function:  AMPA glutamate receptor activity; amyloid-beta binding; ion channel activity; ionotropic glutamate receptor activity; PDZ domain binding; protein binding; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  ion transport; regulation of receptor recycling
Reference #:  Q9Z2W9 (UniProtKB)
Alt. Names/Synonyms: 2900064I19Rik; AMPA-selective glutamate receptor 3; cAMP-dependent Rap1 guanine-nucleotide exchange factor; GluR-3; GluR-C; GluR-K3; Glur3; Gluralpha3; Glutamate receptor 3; glutamate receptor channel alpha3 subunit; Glutamate receptor ionotropic, AMPA 3; glutamate receptor subunit 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); Gria3; Kiaa4184; mKIAA4184
Gene Symbols: Gria3
Molecular weight: 100,527 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene