EXO1 5'- Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 1 H4|1 81.9 cM
Cellular Component:  nuclear body; nucleoplasm; nucleus; plasma membrane
Molecular Function:  5'-3' exodeoxyribonuclease activity; 5'-3' exonuclease activity; 5'-flap endonuclease activity; catalytic activity; chromatin binding; DNA binding; double-stranded DNA 5'-3' exodeoxyribonuclease activity; endonuclease activity; exonuclease activity; flap endonuclease activity; hydrolase activity; hydrolase activity, acting on ester bonds; metal ion binding; nuclease activity; single-stranded DNA 5'-3' exodeoxyribonuclease activity
Biological Process:  cellular response to DNA damage stimulus; DNA recombination; DNA repair; humoral immune response mediated by circulating immunoglobulin; immune system process; isotype switching; meiotic cell cycle; mismatch repair; nucleobase-containing compound metabolic process; somatic hypermutation of immunoglobulin genes
Reference #:  Q9QZ11 (UniProtKB)
Alt. Names/Synonyms: 5730442G03Rik; Exo1; Exonuclease 1; Exonuclease I; mExo1; Msa
Gene Symbols: Exo1
Molecular weight: 92,022 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
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EXO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene