P130Cas Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. Belongs to the CAS family. Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 16q23.1
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; focal adhesion; lamellipodium; ruffle
Molecular Function:  protein binding; protein kinase binding; SH3 domain binding
Biological Process:  actin filament organization; antigen receptor-mediated signaling pathway; B cell receptor signaling pathway; cell adhesion; cell chemotaxis; cell division; cell migration; cellular response to hepatocyte growth factor stimulus; epidermal growth factor receptor signaling pathway; G protein-coupled receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; insulin receptor signaling pathway; integrin-mediated signaling pathway; neurotrophin TRK receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of endothelial cell migration; regulation of apoptotic process; regulation of cell growth; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P56945 (UniProtKB)
Alt. Names/Synonyms: BCAR1; BCAR1 scaffold protein, Cas family member; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; CASS1; CRK-associated substrate; Crk-associated substrate p130Cas; CRKAS; FLJ12176; FLJ45059; p130cas
Gene Symbols: BCAR1
Molecular weight: 93,372 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein