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ANK1
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Isoform Mu17: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain. 17 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell development/differentiation; Endoplasmic reticulum; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 8 A2|8 11.42 cM |
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Cellular Component:
A band; ankyrin-1 complex; axolemma; cortical cytoskeleton; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; M band; membrane; neuron projection; plasma membrane; postsynaptic membrane; sarcolemma; sarcoplasmic reticulum; spectrin-associated cytoskeleton; Z disc
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Molecular Function:
ATPase binding; cytoskeletal anchor activity; enzyme binding; protein binding; protein phosphatase binding; spectrin binding; transmembrane transporter binding
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Biological Process:
endoplasmic reticulum to Golgi vesicle-mediated transport; erythrocyte development; inorganic cation transmembrane transport; multicellular organismal-level iron ion homeostasis; porphyrin-containing compound biosynthetic process; positive regulation of organelle organization; protein localization to plasma membrane; signal transduction
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Reference #:
Q02357
(UniProtKB)
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Alt. Names/Synonyms: Ank; ANK-1; Ank1; ankyrin 1, erythroid; Ankyrin-1; Erythrocyte ankyrin; nb; normoblastic anemia; pale
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Gene Symbols: Ank1
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Molecular weight:
204,227 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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