MRGBP Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Belongs to the EAF7 family. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase
Chromosomal Location of Human Ortholog: 2|2 H4
Cellular Component:  H4/H2A histone acetyltransferase complex; NuA4 histone acetyltransferase complex; nucleus
Biological Process:  chromatin organization; histone acetylation; regulation of growth; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q9DAT2 (UniProtKB)
Alt. Names/Synonyms: 1600027N09Rik; AW060503; C80444; MGC118164; MRG-binding protein; MRG/MORF4L-binding protein; Mrgbp; OTTMUSP00000017539; RIKEN cDNA 1600027N09 gene
Gene Symbols: Mrgbp
Molecular weight: 22,436 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
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MRGBP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene