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CKAP5
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments. Belongs to the TOG/XMAP215 family. Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 2|2 E1 |
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Cellular Component:
centrosome; chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; dendrite; kinetochore; microtubule plus-end; neuronal ribonucleoprotein granule; nucleolus; perikaryon; plasma membrane; protein-containing complex; spindle pole
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Molecular Function:
microtubule binding; microtubule plus end polymerase; microtubule plus-end binding; ribonucleoprotein complex binding
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Biological Process:
cell cycle; cell division; central nervous system myelin formation; centrosome cycle; centrosome duplication; cytoplasmic translation; dendritic spine maintenance; establishment or maintenance of microtubule cytoskeleton polarity; excitatory postsynaptic potential; habituation; locomotory behavior; long-term synaptic potentiation; microtubule polymerization; mitotic spindle organization; mRNA localization resulting in post-transcriptional regulation of gene expression; positive regulation of endocytosis; positive regulation of microtubule nucleation; protein-RNA complex assembly; spindle organization; visual learning
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Reference #:
A2AGT5
(UniProtKB)
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Alt. Names/Synonyms: 3110043H24Rik; 4930432B04Rik; Ckap5; cytoskeleton associated protein 5; Cytoskeleton-associated protein 5; D730027C18Rik; mKIAA0097; T25636
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Gene Symbols: Ckap5
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Molecular weight:
225,635 Da
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Basal Isoelectric point:
8.17
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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