C1QA C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4 D3|4 69.05 cM
Cellular Component:  cell; collagen trimer; extracellular region; postsynapse; synapse
Molecular Function:  protein binding
Biological Process:  aging; complement activation, classical pathway; complement-mediated synapse pruning; immune system process; innate immune response; neuron remodeling; positive regulation of astrocyte activation; positive regulation of microglial cell activation; positive regulation of neuron death; synapse organization; synapse pruning; vertebrate eye-specific patterning
Reference #:  P98086 (UniProtKB)
Alt. Names/Synonyms: AI255395; C1q; C1qa; Complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; OTTMUSP00000010321
Gene Symbols: C1qa
Molecular weight: 25,974 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene