BLNK an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component:  cytoplasmic ribonucleoprotein granule; cytosol; plasma membrane
Molecular Function:  protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  B cell differentiation; humoral immune response; inflammatory response; intracellular signal transduction; positive regulation of signal transduction
Disease: Agammaglobulinemia 4, Autosomal Recessive
Reference #:  Q8WV28 (UniProtKB)
Alt. Names/Synonyms: B cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker; B-cell linker protein; BASH; BLNK; BLNK-S; Cytoplasmic adapter protein; LY57; MGC111051; SLP-65; SLP65; Src homology 2 domain-containing leukocyte protein of 65 kDa
Gene Symbols: BLNK
Molecular weight: 50,466 Da
Basal Isoelectric point: 8.18  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene